Botulinum toxin type A treatment for Raynaud’s phenomenon and other novel dermatologic therapeutic applications

warm-up time after exposure to cold ( 5 ), controls rest pain, shortens and reduces frequency and severity attacks ( 6 ) including stiffness, numbness, acute pain, color change, and swelling ( 7 ), prevents impending infarction of digits and successfully heals ischemic ulcerations caused by profound vasospasm in the majority of patients ( 1 ). These favorable changes of improved perfusion are quantified using visual analogue scale (VAS) and confirmed by digital surface temperature readings ( 1 , 2 ), imaging studies with laser Doppler interferometry ( 3 ), intravascular arteriography, or high-resolution digital magnetic resonance angiography ( 1 ). The adverse events reported are rare and include mild and temporary hand weakness. Amelioration of pain improves hand function despite occasional muscle weakness ( 1 ).